
755 nm + 1064 nm · Dual-Blend® · Fitzpatrick I–VI
The Golden Standard
of Zye.
Two of the most trusted laser wavelengths in aesthetics, 755 nm and 1064 nm, in one compact system that blends them in a single shot. Treat hair, vessels and pigment on every skin type, then add handpieces as your practice grows.
Includes the first HandPico technology to bring tattoo removal and pigmentation solutions to your clinic.

Alexandrite + Nd:YAG in One Cart
TWO WAVELENGTHS.
ONE FOOTPRINT.
ZYE Ultra pairs a 755 nm Alexandrite cavity with a 1064 nm Nd:YAG cavity, so you no longer have to choose between them. Use either wavelength alone, or blend both in the same shot for treatments on every phototype, any time of year.
Both wavelengths in the same pulse, in proportions you adjust, so energy is tailored to the indication and the patient's skin type.
GUIDELINES mode recommends settings based on the handpiece, the clinical indication and the skin phototype.

Sapphire contact and air cooling are built into the handpieces. There's nothing to reorder between patients.
A compact cart that adds handpieces as your treatment menu expands, from hair removal to tattoo, pigment and texture.

Picosecond Laser · 1064 nm + 532 nm
HandPico®
The first picosecond laser built as a handpiece.
Picosecond lasers have always been full standalone systems. HandPico puts picosecond energy into a handpiece that plugs into your ZYE Ultra, adding tattoo removal and pigment treatment without adding another machine to your room.
- 530 ps picosecond pulse, plus a 2.5 ns mode
- 1064 nm spots of 3, 5 and 7 mm; 532 nm spots of 3 and 5 mm
- 6×6 mm fractional microlens array handpiece
- Tattoo removal, benign pigmented lesions, acne scars and wrinkles
- Face and body, Fitzpatrick I–VI
- No consumables
The Science
HOW ZYE ULTRA
WORKS IN THE SKIN.
Each wavelength is absorbed by different targets at different depths. ZYE Ultra lets you choose one, the other, or a blend of both, then protects the skin's surface while the energy works below.
Dual-Blend® Technology
Two Wavelengths, One Shot
YAG or Alexandrite? You no longer have to choose.
ZYE Ultra delivers 1064 nm and 755 nm together in fully adjustable, synchronized proportions, combining the strengths of both wavelengths in a single pulse. Shift the blend toward 755 nm for melanin-rich targets, or toward 1064 nm when you need depth and a gentler approach on darker skin.
- 755 nm: highly efficient for hair, pigmented lesions and superficial vascular lesions, especially in lighter phototypes
- 1064 nm: superficial and deep vascular lesions and collagen stimulation, safe for all phototypes including tanned skin
- Blend proportions are fully adjustable for each indication
- Use either wavelength on its own when that's the better fit
Fitzpatrick I–VI · Year-Round
Every Skin Type, Any Season
Treat the patients you've been turning away.
With two wavelengths in one system, ZYE Ultra treats all phototypes without restriction, at any time of year. GUIDELINES mode adjusts its parameter recommendations to the clinical indication and the patient's skin phototype for more precise, consistent treatments.
- Validated for Fitzpatrick skin types I through VI
- 1064 nm for darker and tanned skin
- 755 nm for lighter skin, where it is most efficient
- Automatic parameter recommendations by indication and phototype
Laser Hair Removal
Why Hair Removal Is a Series
Each session catches a new wave of growing hair.
The laser targets pigment in hair that is actively growing. At any moment only some follicles are in that phase, so sessions are spaced to reach each follicle as it cycles in. Patients typically see reduction after the first few appointments, once all three phases of the growth cycle have been addressed.
- 6–8 sessions, spaced 4–6 weeks apart
- Semi-permanent reduction; results vary by patient
- Spot sizes from 3 to 26 mm, with large-area handpieces for backs and legs
- No downtime and minimal discomfort
- Practices typically charge $90–$1,000 per area, with full-body packages from $4,000–$10,000
Cooling & Safety
Cooling Built Into the Tip
Comfort for the patient. Nothing to refill for you.
The sapphire window on ZYE Ultra's contact handpieces chills the skin's surface while laser energy passes through to its target, helping protect the epidermis and keep treatments comfortable. Cooling uses no cryogen and no consumables.
- Sapphire COOL-&-CLEAR® contact cooling on the 3-10/VL and 8-18/HR
- Epidermal air-cooling adapter on the 3-24/HR
- ACCUSENSE® real-time skin temperature monitoring on the 3-24/HR and 5-15/LT
- No cryogen canisters to buy or replace
Expandable System
A Zye That Can Do Anything
Start with what you need. Add the rest as you grow.
ZYE Ultra runs every handpiece the 755 nm and 1064 nm ZYE systems can, including four fiber-optic handpieces made exclusively for ZYE and the ETHEREA-MX® handpiece lineup. Each one you add opens a new category of treatments, from hair removal patients to tattoo, pigment and texture work.
- Four exclusive fiber-optic handpieces for hair, vascular and rejuvenation
- Compatible with the ETHEREA-MX® handpiece lineup
- Plug-and-play: add handpieces without replacing the system
- Easy upsell from hair removal to fractional and resurfacing treatments
Compatible Handpieces
BUILD YOUR
GOLDEN STANDARD.
Choose the handpieces your practice needs today and add more as you grow. Every handpiece below works on ZYE Ultra.
Hair Removal · Fiber-Optic
8-18/HR®
Square Top Hat beam
Contact cooling, on-handpiece spot changes and a square beam for even coverage.
- FLAT-FRAME® square spot: 25% larger treatment area
- ZYE TELESCOPE® digital optical zoom
- Sapphire COOL-&-CLEAR® contact cooling
Vascular · Fiber-Optic
3-10/VL®
Top Hat beam · 5 spot sizes
Built for vascular lesions, with contact cooling and long or short pulses.
- Sapphire COOL-&-CLEAR® contact cooling
- Long- and short-pulse modes
- Digital zoom between spot sizes
Large-Area Hair Removal · Fiber-Optic
3-24/HR®
Spots from 3 to 24 mm
Plug-and-play spots for small areas through backs and legs, for much faster large-area treatments.
- Plug-and-play spot changes
- ACCUSENSE® real-time skin temperature sensor
- Epidermal cooling adapter
Rejuvenation & Tightening · Fiber-Optic
5-15/LT®
INTENSE® continuous mode
Deep rejuvenation with intense, effective heating of the deeper skin layers.
- Laser tightening in INTENSE® mode
- ACCUSENSE® sensor and aiming laser with distance control
- DYNAMICS® short-pulse mode and cooling adapter
Picosecond Laser
HandPico®
1064 + 532 nm · 530 ps
The first picosecond laser engineered as a handpiece.
- Tattoo removal
- Benign pigmented lesions
- Acne scars and wrinkles
Q-Switched Nanosecond
AcromaQS®
1064 + 532 nm · 20 ns
Photoacoustic energy shatters pigment so the body can clear it.
- Tattoo removal
- Benign pigmented lesions and melasma
- Fractionated 9 mm handpiece
Long & Short Pulse
LongPulse®
Nd:YAG 1064 nm
Multiple spot sizes and pulses up to 60 ms for vessels of different sizes and depths.
- Face and leg veins, rosacea
- Hair removal on darker skin
- DYNAMICS® mode for onychomycosis
Intense Pulsed Light
IPL-Sq®
400–1200 nm · 5 filters
Square-wave pulse IPL with automatic filter recognition for quick, simple photofacials.
- Pigment and sun damage
- Redness and vascular concerns
- Sapphire contact cooling, Fitzpatrick I–IV
Non-Ablative Fractional
ProDeep®
Nd:YAP 1340 nm
Non-ablative resurfacing that expands texture correction to darker skin types.
- Lines, wrinkles and scarring
- Texture and active acne
- Fitzpatrick I–VI
Ablative Fractional
DualMode®
Er:YAG 2940 nm
Ablative fractional laser with ATHENA®, InLift® and TrueLift® spots.
- 12 mm collimated spot for minimally ablative treatments
- 8 mm fractional spot for perioral and periorbital areas
- 2x higher repetition rate for ATHENA® and InLift®
Non-Ablative Fractional
GoSmooth®
Er:Glass 1540 nm
Non-ablative fractional laser for skin renewal.
Infrared Light
IntenseIR®
850–1800 nm
High-power broadband infrared light.
100+ Treatment Indications
TREAT MORE.
GROW MORE.
Hair removal and vascular treatments come built in. Add handpieces to extend ZYE Ultra into pigment, tattoo, texture and tightening across the face and body.
Hair Removal
Blended 755 and 1064 nm for light and dark skin types alike.
Vascular Lesions
Superficial and deep vascular lesions with the 3-10/VL and LongPulse.
Spider & Leg Veins
LongPulse reaches vessels of different sizes on the face and lower limbs.
Rosacea & Redness
LongPulse and IPL-Sq calm broken capillaries and diffuse redness.
Pigmented Lesions
HandPico, AcromaQS and IPL-Sq target sunspots and uneven tone.
Tattoo Removal
Picosecond HandPico and Q-switched AcromaQS break up ink.
Melasma
AcromaQS addresses melasma on Fitzpatrick I–VI.
Acne Scars
ProDeep and HandPico remodel scarring and uneven texture.
Wrinkles & Fine Lines
Fractional options from ProDeep, DualMode and GoSmooth.
Laser Tightening
The 5-15/LT heats deeper skin layers in INTENSE® mode.
Active Acne
ProDeep non-ablative fractional treatment on all skin types.
Onychomycosis
LongPulse in DYNAMICS® mode for nail fungus.
From the Clinicians
WHAT PROVIDERS
ARE SAYING.
Feedback from dermatologists treating patients on ZYE.
Using combined wavelengths in the same device and at the same time is new to me and has brought many advantages. First, you can work with less energy to obtain results similar to those achieved with more energy, which means less pain and less downtime. Second, it is an extremely fast system, allowing us to offer a more accessible treatment without occupying the room for long. Third, it offers great versatility and adds safety. I also highlight that with ZYE Ultra® I observed no side effects, even when using high energies and across all age groups.
We have incorporated the VYDENCE ZYE platform in our office and it has been super successful. The handPICO has quickly become an office favorite for low-density lentigines and melasma, plus the versatility for tattoo removal. The ProDeep handpiece has been huge for non-ablative fractional help with acne scars when patients don't want any downtime.

The ZYE Family
START WITH ONE.
OR GET BOTH.
ZYE also comes as a 755 nm-only or 1064 nm-only system. ZYE Ultra puts both in one cart and runs every handpiece either version can.
- 755 nm ZYE: hair removal, pigment and superficial vascular
- 1064 nm ZYE: vascular, collagen stimulation and all phototypes
- ZYE Ultra: both wavelengths, blended in one shot
- No consumables across the ZYE lineup
By the Numbers
ZYE ULTRA®
AT A GLANCE
Manufacturer: VYDENCE Medical · Distributed by MRP
Available Through MRP
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