ZYE ALX · ZYE YAG · SmartLASER Technology
High-performance lasers.
Intelligent by design.
The ZYE Laser® family features VYDENCE's innovative SmartLASER technology — enabling quick, safe, and effective treatments while capturing real-time IoT analytics. Choose the ZYE ALX® for advanced alexandrite hair removal, or the ZYE YAG® for versatile Nd:YAG indications. Both are compatible with all VYDENCE handpieces and include no consumables, ever.
ZYE ALX® · 755 nm
ZYE YAG® · 1,064 nm
High-Performance Laser Platforms by VYDENCE
SUPER POWERFUL.
SUPER INTELLIGENT.
The ZYE Laser® platforms bring next-generation intelligence to clinical laser treatments — combining near-100 treatment indications with proprietary SmartLASER technology, the most complete handpiece ecosystem in the industry, and the only 2-year comprehensive warranty in the category.
Higher energy even on larger spot sizes — enhancing treatment efficacy regardless of the treatment area.
Optimize practice revenue and focus on delivering patient results — zero per-shot or consumable costs.
SmartLASER technology enables remote technical monitoring and real-time IoT analytics for platform usage management.
Nearly 100 indications per platform, suitable for all skin types and usable year-round — maximizing ROI.
Two Platforms. One Ecosystem.
CHOOSE YOUR
ZYE PLATFORM.
Both ZYE platforms share the same handpiece ecosystem, SmartLASER intelligence, and no-consumables promise — differentiated by wavelength and primary indication focus.
Alexandrite · 755 nm
Advanced 755 nm alexandrite laser platform engineered for fast, comfortable hair removal on Skin Types I–IV — with versatile pigmentation and vascular capabilities. Compatible with all VYDENCE handpieces plus 4 next-generation fiber optic handpieces. Contact cooling and color air chiller options available.
- 755 nm alexandrite — ideal for Skin Types I–IV
- Fast, comfortable hair removal across large areas
- Effective on brown spots and pigmented lesions
- 3 fiber delivery choices for long- and short-pulse
- Contact cooling + color air chiller options
- Compatible with all VYDENCE handpieces
- SmartLASER IoT analytics built in
- No consumables — comprehensive 2-year warranty
Nd:YAG · 1,064 nm
Advanced 1,064 nm Nd:YAG laser platform for skin tightening and rejuvenation, hair reduction across all skin types, and vascular treatments. Compatible with all eight VYDENCE handpieces plus 4 next-generation fiber optic handpieces.
- 1,064 nm Nd:YAG — all skin types, year-round use
- Skin tightening, rejuvenation & pore refinement
- Hair removal across all skin types including darker tones
- Vascular treatments and rosacea
- 4 fiber choices for long- and short-pulse YAG
- Compatible with all 8 VYDENCE handpieces
- SmartLASER IoT analytics built in
- No consumables — comprehensive 2-year warranty
Proprietary Intelligence
SmartLASER™
Technology
Every ZYE Laser® platform is equipped with VYDENCE's proprietary SmartLASER technology — a connected intelligence layer that goes beyond the treatment room to help you monitor, manage, and grow your laser practice with data-driven confidence.
- Remote technical monitoring — reduce downtime, accelerate support
- Real-time IoT analytics for platform usage and treatment data
- Online platform management from anywhere
- Quick, safe, and effective treatment protocols built in
- Engineered by Brazil's premier laser company — trusted globally
- 2-year comprehensive warranty — the only platform offering full coverage
Next-Generation Fiber Optic Handpieces
EXCLUSIVE ZYE®
HANDPIECE INNOVATIONS.
In addition to the full shared VYDENCE handpiece ecosystem, ZYE platforms include four proprietary next-generation fiber optic handpieces with exclusive technologies unavailable on any other platform.
3-10/VL® · 8-18/HR®
ZYE Telescope® System
The ZYE Telescope® integrates digital optical zoom directly into the handpiece, enabling fast, tool-free spot size adjustment across different treatment areas without interrupting the session. Larger spot sizes maintain full energy delivery — no trade-off between coverage area and fluence. Ideal for providers who need to move efficiently between facial and body zones within a single appointment.
8-18/HR®
FLAT-FRAME® Technology
Traditional round laser spots leave gaps between pulses, requiring overlapping passes that slow treatment and risk uneven coverage. FLAT-FRAME® uses a square spot geometry to eliminate those gaps entirely — delivering a 25% larger effective treatment area per pulse with seamless, uniform coverage. The result is faster sessions, fewer passes, and more consistent outcomes across large body areas like the back, legs, and chest.
3-10/VL® · 8-18/HR®
COOL-&-CLEAR® Sapphire
COOL-&-CLEAR® uses an integrated sapphire contact cooling window that chills the skin surface immediately before, during, and after each pulse — protecting the epidermis while allowing higher fluences to be delivered safely at depth. Unlike gel-based cooling or external cryo devices, the sapphire tip maintains direct skin contact throughout treatment, ensuring consistent thermal protection and enhanced procedural safety without interrupting the workflow.
3-24/HR®
3-24/HR® Large-Area Handpiece
The 3-24/HR® delivers plug-and-play spot sizes up to 24 mm in diameter — one of the largest available in the category — with integrated air cooling for continuous comfortable delivery. Its large spot footprint dramatically reduces the number of pulses needed to cover the back, thighs, or chest, cutting treatment time significantly. With 11 available spot size configurations and an epidermal cooling adapter that requires no consumables, it's optimized for high-volume hair removal practices.
5-15/LT® · 3-24/HR®
AccuSense® Sensor
AccuSense® provides real-time, continuous skin temperature monitoring throughout treatment — not just a single pre-treatment reading. The sensor dynamically reads surface temperature pulse-by-pulse and allows the provider to set customizable safety thresholds, automatically flagging deviations before they become a safety concern. This level of real-time feedback is particularly valuable when treating variable tissue types, darker skin tones, or large body areas where skin response can shift across the session.
5-15/LT® · ZYE YAG Only
Distance Control Guide
The 5-15/LT® handpiece includes an integrated laser guide with distance control — ensuring the handpiece is held at the precise focal distance from the skin surface during non-contact rejuvenation and tightening treatments. This removes operator variability from the equation: every pulse lands at the correct depth, every time. The result is more reproducible outcomes session-to-session, better depth targeting for collagen stimulation, and a significant reduction in user technique-dependent variation.
Full Shared Ecosystem
Also Compatible With
All VYDENCE Handpieces
ZYE platforms share the same plug-and-play handpiece ecosystem as the Etherea MX® — meaning any handpiece you add works across your entire VYDENCE investment.
~100 Indications Per Platform
TREAT MORE.
GROW MORE.
ZYE Laser® platforms address a comprehensive range of aesthetic indications — across hair, vascular, pigmentation, and skin renewal — suitable for all skin types and usable year-round.
Hair Removal
Fast, comfortable permanent hair reduction. ZYE ALX excels on Types I–IV; ZYE YAG covers all skin types year-round.
Vascular Lesions
Nd:YAG 1,064 nm and IPL-Sq® target spider veins, rosacea, and diffuse redness effectively.
Pigmented Lesions
Alexandrite and Nd:YAG wavelengths address sunspots, lentigines, and unwanted brown spots precisely.
Skin Rejuvenation
Nd:YAG 1,064 nm stimulates collagen for overall skin tone improvement, pore refinement, and radiance.
Skin Tightening
Long-pulse Nd:YAG with distance control guide delivers deep thermal energy for laxity and tightening.
Rosacea
3-24/HR® handles vascular lesion treatments and rosacea with plug-and-play ease across large areas.
Acne Scars
ProDeep® and DualMode® handpieces treat acne scars and non-ablative fractional resurfacing with no downtime.
All Skin Types
ZYE YAG treats all Fitzpatrick skin types. ZYE ALX ideal for Types I–IV. Combined: comprehensive coverage.
Clinically Proven Results
REAL RESULTS.
REAL PATIENTS.
Individual results may vary. Each treatment is tailored to the patient's specific concerns, skin type, and protocol.
* Results may vary. Individual outcomes depend on treatment protocol, skin type, and patient compliance. Images courtesy of VYDENCE® Medical and contributing physicians.
Trusted by Laser Experts
TRUSTED BY CLINICIANS
ACROSS THE COUNTRY
Real feedback from physicians and providers who've incorporated VYDENCE ZYE platforms into their practices.
We have incorporated the VYDENCE ZYE platform in our office and it has been super successful. One of the standouts has been the handPICO, which has quickly become an office favorite for low-density lentigines and melasma, plus the versatility for tattoo removal. The ProDeep handpiece has been huge for non-ablative fractional help with acne scars when patients don't want any downtime.
I'm finding it remarkable in that it's very flexible, has minimum downtime and provides a high level of patient comfort. The ProDeep® 1340-nm handpiece gives us a wavelength that is unique to the US market — we're now able to effectively treat conditions we weren't able to in the past, like acne and hidradenitis suppurativa. It should be the core piece of any practice.
The DualMode handpiece was an obvious decision for me and we use it daily. The handpiece's hybrid system significantly removes sun damage with a single treatment and minimal downtime. It meets the needs of both providers and patients, offering dramatic results with little to no recovery time.
The versatility and performance of this platform have exceeded my expectations. I'm excited to continue exploring all that these powerful technologies have to offer and to see the growing impact on my patients' skin health and confidence.
The handPICO has been a game changing addition to my practice! It allows me to treat a broader range of patients in regards to skin toning and melasma. Tattoo removal has been incredible with the handPICO, offering an easy to customize treatment for the patient.
I really like how flexible the platform is and how tolerable the treatments are for my patients. It's also helpful that the platform is compact with a small footprint but is very powerful. We're seeing great results with DualMode, ProDeep and handPICO!
By the Numbers
ZYE LASER®
AT A GLANCE
Manufacturer: VYDENCE Medical · Distributed by MRP
Available Through MRP
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